RecruitingNCT06564428

A Cohort Study of Hereditary Ovarian Cancer Risk Prediction Models and Pathogenesis Exploration


Sponsor

Peking University Third Hospital

Enrollment

1,000 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The aim of this project is to establish a bidirectional multicenter cohort of hereditary ovarian cancer and to describe the clinicopathologic features of hereditary ovarian cancer patients in our country. The risk prediction model of ovarian cancer for Chinese was established by following-up analysis of clinical and pathological information, genetic test results and detailed family history, to predict the risk of cancer in first-degree relatives of carriers of pathogenic/suspected pathogenic mutations, and to guide the intervention management of high-risk population of cancer. The study will identify novel tumor-causing mutations/predisposing genes by gene sequencing in a special family with hereditary tumor.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is developing a better model to predict the risk of hereditary ovarian cancer in women who have been diagnosed with epithelial ovarian cancer and carry known genetic mutations. The goal is to improve genetic counseling and guide screening recommendations for patients and their family members. **You may be eligible if...** - You are 18 or older - You have been diagnosed with epithelial ovarian cancer (the most common type) - You have had genetic testing that identified a pathogenic or likely pathogenic mutation - Your diagnosis has been confirmed by a pathologist **You may NOT be eligible if...** - Your ovarian cancer is confirmed to be a non-epithelial type (such as germ cell or stromal tumors) - You have not had genetic testing performed Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICSuspective gene mutations and family history

To observe if the patients with suspective gene mutations or family history take higher risk of suffering from ovarian cancer.


Locations(1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

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NCT06564428


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