A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of MSD-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL

This study is comparing two types of stem cell transplant conditioning regimens in children aged 1–17 with acute lymphoblastic leukemia (ALL — a type of blood cancer) who are in complete remission and have a matched sibling donor available, to see which approach leads to better outcomes with fewer complications. **You may be eligible if...** - You are age 1–17 and have been diagnosed with ALL (a type of leukemia) - Your leukemia is in complete remission (cancer not detectable in blood) - You have a fully matched sibling who can donate stem cells - You are in reasonably good health (Karnofsky score ≥70) - Your heart, liver, kidney, and lung function are within acceptable ranges **You may NOT be eligible if...** - Your leukemia is not in remission - You do not have a matched sibling donor - You have significant organ problems affecting the heart, liver, or kidneys - You have active, uncontrolled infection - You have previously had a stem cell transplant Talk to your doctor to see if this trial is right for you.