RecruitingNot ApplicableNCT06565143

Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease


Sponsor

Anhui Medical University

Enrollment

40 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease


Eligibility

Min Age: 50 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether transcranial alternating current stimulation (tACS) — a gentle, non-invasive brain stimulation technique using a mild electrical current applied to the scalp — can improve memory and thinking in patients with early Alzheimer's disease or related conditions who are already taking standard medication. **You may be eligible if...** - You have been diagnosed with early Alzheimer's disease or a related cognitive condition - Your cognitive test scores fall in the mild impairment to early dementia range (MMSE score 10–27) - You have been taking a cholinesterase inhibitor medication (like donepezil) for at least 3 months - Any other psychiatric medications you take have been at a stable dose for at least 3 months **You may NOT be eligible if...** - Your dementia is at a more advanced stage (CDR score above 2) - You have a history of severe psychiatric illness, seizures, or unexplained loss of consciousness - You have a pacemaker, deep brain stimulator, or medication pump implanted in your body - You have had a stroke or other neurological brain disease - You have had a substance abuse problem in the past 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial alternating current stimulation

Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation tool that alters cortical excitability and activity via application of weak alternating currents.

DEVICESham transcranial alternating current stimulation

In the sham condition, tACS was delivered only during the ramp-up and ramp-down periods (30s); no current was delivered during the 30-minute intervention.


Locations(1)

Anhui Medical University

Hefei, Anhui, China

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NCT06565143


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