Evaluation of PSMA-PET and mpMRI in High-risk Prostate Cancer - Using Histopathologic Validation

This study is evaluating whether combining a PSMA-PET scan (a highly sensitive nuclear imaging test for prostate cancer) with a multiparametric MRI (a detailed MRI specifically for prostate) is better than either test alone at detecting if prostate cancer has spread beyond the prostate before surgery in men with high-risk disease. **You may be eligible if...** - You are 18 or older with confirmed prostate cancer that is planned to be treated with surgical removal of the prostate - Your cancer is classified as high-risk (T3 stage, Gleason score ≥8, or PSA between 20–49) - You have already had or are scheduled for a PSMA-PET scan as part of your standard care **You may NOT be eligible if...** - You have metal implants that are not safe for MRI, or you have claustrophobia - You are already on hormone therapy (anti-testosterone treatment) - Your cancer has already spread to bones, organs, or lymph nodes outside the pelvis - You have had another cancer diagnosis (with limited exceptions) - Your kidney function is significantly impaired - You have tinnitus or severe hearing loss Talk to your doctor to see if this trial is right for you.