A Multi-mode Thermophysical Immunotherapy Study for Breast Cancer Liver Metastases

This study tests a combination of heat-based and immune-boosting treatments for breast cancer that has spread to the liver. It is designed for patients who cannot or do not want to have surgery to remove the liver tumors. **You may be eligible if:** - You are a woman between 18 and 75 years old - Your breast cancer has spread to the liver and surgery is not an option - You have no more than 3 liver tumors, each smaller than 4 cm - Your liver function is reasonably good (Child-Pugh class A or B) - It has been at least 1 month since your last local treatment - You are in fair general health (ECOG score 2 or lower) with a life expectancy over 3 months **You may NOT be eligible if:** - Your liver is severely damaged (Child-Pugh class C) - Your cancer has spread widely and your life expectancy is less than 3 months - You had bleeding from esophageal varices in the past month - You have major organ failure, active infection, or severe fluid buildup - You are pregnant or unable to cooperate with treatment Talk to your doctor to see if this trial is right for you.