Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study

This study tests a minimally invasive procedure called superselective adrenal artery embolization — where tiny particles are used to block blood flow to part of the adrenal gland — as a treatment for people with very high blood pressure that does not respond to multiple medications. The adrenal glands produce hormones that regulate blood pressure, and this procedure aims to reduce their activity. **You may be eligible if:** - You are over 18 years old - You have primary (essential) hypertension that is "refractory" — meaning your blood pressure stays at or above 150 mmHg systolic despite taking three blood pressure medications (including a diuretic) - You have had high blood pressure for more than 6 months - Your aldosterone and renin levels are within a normal range **You may NOT be eligible if:** - Your kidney function is significantly reduced (eGFR below 45) - You have potassium levels that are too high - You have type 1 diabetes, uncontrolled thyroid problems, serious heart rhythm problems, advanced heart failure, or recent history of heart attack or stroke - Your morning cortisol level is too low Talk to your doctor to see if this trial is right for you.