RecruitingNot ApplicableNCT06570824

rTMS as an Intervention for Levodopa-induced Dyskinesia

Network Based Repetitive Transcranial Magnetic Stimulation (rTMS) as an Intervention for Levodopa-induced Dyskinesia (LID) in Parkinson's Disease (PD)


Sponsor

Danish Research Centre for Magnetic Resonance

Enrollment

68 participants

Start Date

Jul 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study aims to determine whether patterned stimulation of the pre-supplementary motor area (pre-SMA) can delay the onset of LID after levodopa intake and reduce LID severity in PD patients. This study will provide critical insights into potential targets for rTMS treatment, optimal rTMS parameters, and the mechanisms underlying LID in Parkinson's disease.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique using magnetic pulses on the scalp — can reduce involuntary movements (dyskinesia) caused by levodopa, the main medication for Parkinson's disease. These uncontrolled movements can significantly impact quality of life. **You may be eligible if:** - You have a confirmed diagnosis of Parkinson's disease - You experience peak-dose dyskinesia — involuntary movements that happen when your levodopa medication is most active - Your Parkinson's medications have been stable for at least 4 weeks - You have signed informed consent **You may NOT be eligible if:** - You have a psychiatric disorder - You take antipsychotic medications, donepezil, or GABAergic drugs (like pregabalin or gabapentin) - You regularly use benzodiazepines or opioids (more than once a week) - You have epilepsy or conditions that increase seizure risk - You have contraindications to MRI (metal implants, pacemaker) - You are pregnant or of childbearing age without contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEactive TMS

Transcranial magnetic stimulation using MagVenture XP Orange Stimulator using active side of MagVenture Cool-B70 coil

DEVICEsham TMS

Sham transcranial magnetic stimulation using MagVenture XP Orange Stimulator, flipping the active side of the MagVenture Cool-B70 coil


Locations(1)

DRCMR

Hvidovre, Denmark

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06570824


Related Trials