RecruitingNCT06574698

Adding Of Naxitamb In Induction Therapy For High Risk Neuroblastoma

Adding Of Naxitamb In Induction Therapy For High Risk Neuroblastoma: A Prospective, Single-Arm Clinical Study


Sponsor

Guangzhou Women and Children's Medical Center

Enrollment

64 participants

Start Date

May 6, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

To explore the efficacy of adding anti-GD2 immunotherapy (Naxitamab) at the stage of induction chemotherapy for newly diagnosed high risk neuroblastoma patients. To investigate wether anding Naxitamab in the induction phase will improve the response rate at the end of induction therapy and further improve the overall survival rate.


Eligibility

Min Age: 1 YearMax Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study adds a drug called naxitamab (an antibody that targets cancer cells) to the standard induction chemotherapy for children with high-risk neuroblastoma — a cancer of the nervous system that most commonly affects young children. The goal is to improve initial response rates. **You may be eligible if...** - Your child has been newly diagnosed with high-risk neuroblastoma (stage 3 or 4 per INSS criteria) - Your child meets specific age and biological risk criteria (such as MYCN amplification or specific tumor features) - Your child has not yet received treatment for this diagnosis **You may NOT be eligible if...** - Your child has already received treatment for neuroblastoma - Your child's cancer does not meet the high-risk criteria for this trial - Your child has serious health problems that would make treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAddition of anti-GD2 immunotherapy (Naxitamab) at the stage of induction chemotherapy

Addition of anti-GD2 immunotherapy (Naxitamab) at the stage of induction chemotherapy


Locations(1)

Guangzhou Women And Children's Medical Center

Guanzhou, Guangdong, China

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NCT06574698


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