RecruitingPhase 1NCT06577987

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

A Phase 1, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of the Oral Cyclin A/B-RxL Inhibitor CID-078 in Patients With Advanced Solid Tumor Malignancies


Sponsor

Circle Pharma

Enrollment

220 participants

Start Date

Aug 14, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a first-in-human, multicenter, open-label, phase 1 study to evaluate safety, tolerability, and efficacy of CID-078, a Cyclin A/B-RxL inhibitor, in patients with advanced solid tumors.


Eligibility

Min Age: 12 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an experimental cancer drug called CID-078 in people with advanced solid tumors that have stopped responding to standard treatments, to evaluate its safety, how the body processes it, and early signs of effectiveness. **You may be eligible if...** - You are 18 years or older - You have an advanced or metastatic solid tumor that has progressed on or is no longer responding to available treatments - You have adequate organ function (liver, kidneys, blood counts) - You are in reasonably good physical health **You may NOT be eligible if...** - You have received certain prior treatments within a required washout period - You have active brain metastases - You have serious infections or autoimmune conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCID-078 Monotherapy

Cyclin A/B-RxL inhibitor, twice-a-day in repeating 21-day treatment cycles until disease progression or discontinuation criteria.


Locations(10)

Florida Cancer Specialists

Sarasota, Florida, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

START Midwest

Grand Rapids, Michigan, United States

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, United States

UH Seidman Cancer Center

Cleveland, Ohio, United States

Oregon Health and Science University

Portland, Oregon, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

MD Anderson Cancer Center

Houston, Texas, United States

NEXT Oncology

San Antonio, Texas, United States

START Mountain

West Valley City, Utah, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06577987


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