RecruitingNot ApplicableNCT06580964

Heat and Exercise in Aging as Therapy (HEAT)

Glycemic Control and Frailty Risk in Older People at Risk for Type 2 Diabetes: Impact of Local Heat Therapy


Sponsor

Texas Tech University

Enrollment

54 participants

Start Date

Jul 31, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The main goal of this two-phase clinical trial is to learn whether local heat therapy, using heat pads applied to the legs, can enhance skeletal muscle health, physical function, and blood sugar control in a manner comparable to exercise, specifically High-Intensity Interval Training (HIIT), in older individuals with prediabetes. The study aims to answer the following questions: 1. Does local heat therapy improve muscle architecture (e.g., muscle cross-sectional area, capillary density, mitochondrial content), glucose tolerance, and frailty indicators similarly to HIIT in older individuals with prediabetes? 2. Does local heat therapy as a pre-conditioning method enhance the skeletal muscle response to HIIT in older individuals with prediabetes?


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether combining heat therapy (like sauna or hot baths) with exercise can improve blood sugar control and reduce the risk of developing type 2 diabetes in older, sedentary, postmenopausal women who have prediabetes. Heat therapy alone has shown promise in some studies for improving metabolism. **You may be eligible if...** - You are a woman aged 50 or older who has gone through menopause - You are not currently doing regular structured exercise - You weigh at least 110 pounds - You have prediabetes (fasting blood sugar between 100–125 mg/dL or HbA1c between 5.7–6.4%) **You may NOT be eligible if...** - You have been diagnosed with type 2 diabetes - You have heart disease, uncontrolled high blood pressure, or other serious health conditions - You use medications that affect blood sugar levels (like metformin) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALHeat therapy

Heat pads will be set to a pre-determined, optimized temperature and applied to both legs for 90 min, 6d/wk (5 at-home and 1 in-lab).

BEHAVIORALHigh-intensity interval training

High-intensity interval training will be performed 3 days per week for 12 weeks.


Locations(1)

Texas Tech University

Lubbock, Texas, United States

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NCT06580964


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