Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma

Inclusion Criteria9

• Age 18-80 years, no gender restrictions;
• Diagnosed with refractory/relapsed multiple myeloma through physical examination, pathological examination, laboratory tests, and imaging studies;
• Flow cytometry or histology confirms positive BCMA expression in myeloma cells;
• As judged by the investigator, the expected survival time is \>3 months;
• ECOG performance status score ≤2, KPS \>60%;
• The patient has good liver, kidney, heart, and lung function: ALT and AST ≤2.5×ULN, those with liver involvement can be relaxed to ≤5×ULN; serum total bilirubin \<34 μmol/L; creatinine clearance rate \>30 mL/min; heart ejection fraction (EF) ≥40%, no pericardial effusion and significant arrhythmia; indoor SpO2 ≥92%;
• Peripheral blood lymphocyte absolute count ALC ≥0.5 ×10\^9/L, PLT \>30×10\^9/L, Hb \>80 g/L and has a single collection venous access, and there are no other contraindications for hematopoietic cell separation;
• Those with fertility must agree to use highly effective contraceptive methods;
• The subject or their legal guardian can understand and is willing to sign a written informed consent form voluntarily.