RecruitingPhase 2NCT06581640

Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma

A Clinical Study of the Safety and Efficacy of Chimeric Antigen Receptor-modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma


Sponsor

The First Affiliated Hospital of Xiamen University

Enrollment

5 participants

Start Date

Sep 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the safety and tolerability of chimeric antigen receptor gene-modified T cells targeting BCMA for the treatment of relapsed/refractory multiple myeloma


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests a CAR-T cell therapy targeting a protein called BCMA, which is found on the surface of myeloma cells. CAR-T therapy involves reprogramming a patient's own immune cells to hunt and destroy cancer. This trial is for people with multiple myeloma — a cancer of plasma cells in the bone marrow — that has returned or stopped responding to other treatments. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with relapsed or refractory multiple myeloma - Your myeloma cells have been confirmed to express the BCMA protein - Your overall health (ECOG performance status) and organ function meet the study requirements **You may NOT be eligible if...** - You have active, uncontrolled infection - You have had a prior CAR-T therapy targeting BCMA - You have significant heart, liver, or kidney problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCAR-T treatment

Peripheral blood lymphocyte collection, PBMC separation, BCMA CAR-T cell preparation/storage, lymphodepletion chemotherapy pretreatment for the subject, and BCMA CAR-T cell infusion.


Locations(1)

The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China

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NCT06581640


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