RecruitingNot ApplicableNCT06582199

Precision Medicine in Alzheimer's Disease : Integration of Resilience Metrics and Risk Factors - Validation Cohort BioCogBank-AD

Precision Medicine in Alzheimer's Disease: Integration of Resilience Metrics and Risk Factors - Validation Cohort BioCogBank-AD

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

244 participants

Start Date

Oct 31, 2024

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease

Summary

BioCogBankAD aims at building a prospective clinical practice cohort of 244 patients with biologically confirmed mild cognitive impairment due to Alzheimer's Disease (AD) or mild AD in order to validate data regarding markers of resilience toward AD pathophysiological process discovered in an upstream project called AD-Resilience.

Eligibility

Min Age: 50 YearsMax Age: 90 Years

Inclusion Criteria8

Diagnosis of AD according to IWG-2 2014 criteria
Age 50-90 year old
Affiliated or beneficiary of a social security scheme
MMSE ≥ 20
Abnormal CSF Aβ42 or Aβ40/Aβ42 ratio according to local cut-offs
Abnormal CSF phosphorylated and total Tau according to local cut-offs
Ability to pass neuropsychological assessments
Availability of a brain MRI with T1 volumetric sequence performed within 1 year

Exclusion Criteria3

Other cause of dementia
Participation in an AD therapeutic clinical trial
Protected adults (including individual under guardianship by court order),

Interventions

OTHERBlood sample

Plasma, DNA, RNA and PBMC Sampling

BEHAVIORALNeuropsychological battery tests

* Short term memory: Digit span (forward and backward) * Long term memory: Free and Cued selective reminding Test * Language and semantic Memory : Verbal Fluency (Category and Litteral), Image Naming (DO 40) * Praxis * Visuo Spatial abilities: Rey-Osterrieth Complex Figure Test * Attention and executive functions: Trail Making Test (TMT) Part A and B, Frontal Assessment Battery (FAB) * Autonomy in daily life activities : Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory (ADCS-ADL), Instrumental Activities of Daily Living (IADL) * Mood and anxiety: Hospital Anxiety and Depression Scale (HADS) * Cognitive reserve : Cognitive Reserve Index questionnaire (CRIq)