Evaluation of Biomarkers for Predicting Macronutrient Intake

This study is developing and validating wearable sensors and AI algorithms that can accurately measure levels of macronutrients — proteins, fats, and carbohydrates — in the blood and tissue fluid in real time after a meal, potentially allowing personalized nutrition monitoring without repeated blood draws. Adults aged 50 to 75 with a BMI between 25 and 35 who can walk independently and lie comfortably for extended periods may be eligible, unless they have cancer, diabetes, blood clotting disorders, or other serious health conditions. Participation involves up to 4 study days of about 14 hours each, during which you consume predefined meals, have a small IV catheter and a tissue fluid sampling device placed in your arm, and provide blood samples at set intervals. This summary was prepared to help patients understand the study in plain language.