RecruitingEarly Phase 1NCT06586047

Breast Cancer PSMA PET

Evaluation of PSMA Expression in Triple Negative Breast Cancer Patients Using 18 F-DCFPyL-PET/CT


Sponsor

Ahmad Shariftabrizi

Enrollment

30 participants

Start Date

Aug 29, 2024

Study Type

INTERVENTIONAL

Summary

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a specialized type of PET scan that uses a tracer called PSMA — typically used to image prostate cancer — to see if it can also detect and characterize metastatic triple-negative breast cancer (TNBC). TNBC is an aggressive form of breast cancer that lacks the three most common receptors, making it harder to treat. **You may be eligible if...** - You are a female, 18 or older - You have been diagnosed with distantly metastatic triple-negative breast cancer (TNBC) - Your initial biopsy confirmed the TNBC diagnosis - Your metastatic lesions are FDG-positive on a standard PET/CT scan done in this study **You may NOT be eligible if...** - You have another active cancer - You are unable to tolerate PET/CT imaging - You are pregnant or breastfeeding - Your lesions do not show up on the initial FDG PET scan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPET imaging

Imaging with FDG PET/CT and Pyl PET/CT in triple negative breast cancer


Locations(1)

University of Iowa Healthcare

Iowa City, Iowa, United States

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NCT06586047