Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

This study is comparing whether an AI tool can screen patients with heart failure for clinical trial eligibility just as well as doctors doing it manually. It is not testing a new treatment — it is studying the AI screening process itself using existing patient records from a large hospital network. **You may be eligible if...** - You have a documented diagnosis of heart failure - You had your heart pumping function (ejection fraction) measured within the past 2 years - You have been seen by a Mass General Brigham provider within the last 2 years **You may NOT be eligible if...** - You have a reduced ejection fraction (below 50%) and are already on or cannot tolerate maximum doses of standard heart failure medications - You have a preserved ejection fraction (above 50%) and are already on or cannot tolerate SGLT2 inhibitors - Your last recorded blood pressure was below 90 mmHg (very low) Talk to your doctor to see if this trial is right for you.