A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM

This study is testing a combination approach — using multiple types of ablation (procedures that destroy tumors using heat or cold) along with systemic cancer drugs — for people with colorectal cancer that has spread to the liver and cannot be surgically removed. **You may be eligible if...** - You are between 18 and 75 years old - You have colorectal cancer that has spread to the liver and cannot be or was not surgically removed - You have no more than 5 liver tumors, each measuring 3 cm or less - Your first-line treatment has already stopped working - Your liver function and blood counts are within acceptable limits (Child-Pugh A or B) - You are willing to receive immunotherapy (anti-PD-1) as part of your treatment **You may NOT be eligible if...** - Your liver function is severely impaired (Child-Pugh class C) - Your expected survival is less than 3 months - You have major organ failure or active infection - You have uncontrolled fluid buildup in the abdomen (ascites) or severe muscle wasting Talk to your doctor to see if this trial is right for you.