RecruitingPhase 1NCT06593145
CAR T Cells in the Treatment of Refractory and Relapsed CD19+ B Cell Neoplasms
Application of the Autologous CAR T Cells (Tarcidomgen Kimleucel) in the Treatment of Refractory and Relapsed CD19+ B Cell Neoplasms
Sponsor
FamiCordTx
Enrollment
6 participants
Start Date
May 24, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
One arm, open label study to assess the clinical use of Investigational Medicinal Product FCTX-CL19-1 (scientific name: Tarcidomgen Kimleucel) containing autologous anti-CD19 CAR T cells with a preliminary determination of the safety of intravenous IMP administration in patients diagnosed with refractory and relapsed CD19 + B cell neoplasms.
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria20
- Adult patients 18-65 both inclusive;
- Diagnosis of:
- Refractory B-ALL (acute lymphocytic leukemia) - relapse after hematopoietic cell transplantation, second or more relapse in patients when transplantation is contraindicated)
- Large B-cell lymphoma including DLBCL NOS, lymphoma with high level of malignancy, follicular lymphoma transformed to DLBCL and primary mediastinal lymphoma - refractory or relapse or after at least 2 lines of systemic treatment)
- Mantle cell lymphoma (MCL) - relapsing or refractory after at least 2 lines of systemic treatment; Diagnostics of individual diagnoses (criteria for complete remission and partial responses for individual disease entities) was developed on the basis of current (July 2022) recommendations of experts of the Polish Society of Clinical Oncology
- Confirmed CD19 expression on malignant cells;
- General condition measured by ECOG (Eastern Cooperative Oncology Group) ≤ 1;
- Patient's weight between 40 kg - 130 kg
- Sufficient general condition of organs on screening visit:
- ALT/AST \<2,5 of UNL and bilirubin \<1,5 mg/dl (\<4 mg/dl for patients with Gilbert syndrome)
- Ejection fraction (EF) \>50% confirmed in ECHO with no signs of exudation in pericardium during 6 weeks before screening
- Saturation of arterial blood \>93% with no oxygen insufflation, with no significant exudation in pleural cavity
- Serum creatinine clearance \>60 ml/min (by Cockcroft-Gault formula);
- Negative result for HCV, HBV, HIV, Syphilis;
- Negative test for pregnancy (serum or urine) in the screening visit and/or 7 days before leucapheresis and 7 days before lymphodepleting therapy in women in reproductive age;
- Assumption of at least 12 months of survival time from screening visit;
- Agreement to maintain sufficient method of contraception from the date of signing informed consent to 6 months after CART therapy;
- The last dose of SARS-CoV-2 vaccination taken at least 6 months prior to study enrollment
- Capable of providing written informed consent;
- Patients polish native language speaking or fluent in polish language
Exclusion Criteria19
- Any significant CNS diseases that preceded and not connected with relapse (including seizures, paresis, aphasia, stroke or CNS bleeding, severe brain trauma, dementia, Parkinson's disease, any disease affecting cerebellum, psychosis and diseases involving lack of coordination or movement);
- Bulky or rapidly progressing disease;
- Less than 3 months after allo-HSCT transplantation or DLI before screening;
- The need for high-dose chemotherapy less than 4 weeks before the scheduled apheresis;
- Concomitant presence of another malignancy and another malignancy diagnosed up to 2 years before inclusion to this trial;
- Patient's weight below 40 kg and above 130kg
- Any active bacterial, viral or fungal infection including SARS-CoV2;
- Latent HBV/HCV/HIV/Syphilis infection;
- Any other concomitant disease which in the opinion of the investigator would be interfering with the safety of participant in the trial
- Allergic to penicillin, streptomycin and amphotericin B;
- Intolerance to cyclophosphamide or fludarabine during previous treatment with these drugs;
- Chronic systemic immunosuppression treatment (i.e. cyclosporin). Corticosteroids are allowed up to dexamethasone dose of 4 mg a day or equal of this dose;
- Systemic immunosuppression treatment of acute and/or chronic Graft-versus host disease (GvHD) connected to earlier allogeneic HSCT treatment;
- Pregnancy;
- Women in reproductive age as well as men (regardless of age) that do not agree to maintain effective method of contraception during the trial, lactated women can be included into the trial unless declaration of stopping breast feeding during the whole trial time;
- Unable to provide informed consent for this trial;
- Lack of actual vaccination against SARS-CoV2 by vaccine accepted to use in the EU;
- Patients who are not fluent in polish language;
- Previous use of anti-CD19 CART therapy
Interventions
BIOLOGICALFCTX-CL19-1 (Tarcidomgen Kimleucel)
It will be administered only by Investigators during hospitalization. Each patient will receive one administration of IMP on Day 0: * administration route - intravenous * cell dose: 0,2 x 106 -2 x 106 CAR T cells per kilogram of patient body weight
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06593145
Related Trials
International Study for Treatment of High Risk Childhood Relapsed ALL 2010
NCT0359017115 locations
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
NCT0650027361 locations
CAR-T Followed by Bispecific Antibodies
NCT048897162 locations
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
NCT0513102262 locations
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies
NCT058871671 location