RecruitingPhase 3NCT06593431

Extending Outcomes for Pancreas Cancer Patients With Nominal Oligometastatic Disease (EXPAND): A Randomized Phase III Trial


Sponsor

M.D. Anderson Cancer Center

Enrollment

80 participants

Start Date

Oct 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The EXPAND trial (EXtending outcomes for PAncreas cancer patients with Nominal oligometastatic Disease) is a randomized phase III trial assessing the efficacy of MDT to improve PFS and OS for patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This Phase III study (EXPAND) is testing whether targeted local treatments — such as radiation, surgery, or ablation — to all visible tumor sites can improve survival in patients with pancreatic cancer that has spread to just a few places (called oligometastatic disease). **You may be eligible if...** - You are 18 or older - You have been diagnosed with pancreatic ductal adenocarcinoma (a specific type of pancreatic cancer) - You have between 1 and 5 distant tumor sites that can all be treated with local therapy - Your general health status allows for active treatment (ECOG score 0-2) - All of your tumor sites, including any spread, can be targeted with radiation, surgery, or ablation **You may NOT be eligible if...** - You have more than 5 separate metastatic spots - Any of your tumors cannot be safely treated with local therapy - Your general health is too poor to tolerate treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONConsolidative Radiation

Participants will receive treatment through radiation therapy


Locations(1)

MD Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT06593431


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