RecruitingNCT06594250

Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia


Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Enrollment

405 participants

Start Date

Sep 2, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Antibiotic treatment, a biological treatment called Intracellular reservoir test, and others for people with bacteria infection mechanism. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTNasal swab

Nasal swab to detect nasal carriage of S. aureus

BIOLOGICALVenous sampling

Peripheral venous sampling to collect peripheral blood mononuclear cells.

BIOLOGICALAntibiotic treatment

Antibiotic treatment for bacteremia (+/- 1 month), in all patients with S. aureus

DEVICENasal swab

A new nasal swab will be taken using the same technique, to see whether or not the carriage persists

BIOLOGICALIntracellular reservoir test

In the event of positive carriage, a new intracellular reservoir test will be performed. A search for relapse (new S. aureus infection) or recurrence (S. aureus bacteremia if the 1st bacteremia was due to another pathogen) will be carried out.


Locations(1)

Centre Hospitalier Universitaire de St Etienne

Saint-Etienne, France

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NCT06594250