Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia
Centre Hospitalier Universitaire de Saint Etienne
405 participants
Sep 2, 2024
OBSERVATIONAL
Conditions
Summary
Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population.
Eligibility
Inclusion Criteria3
- Bacteremia
- Patient affiliated or entitled to a social security plan
- Patient who has signed a consent form to participate in the study.
Exclusion Criteria5
- Antibiotic therapy in place for more than 5 days at the time of inclusion
- Nasal decolonization of S. aureus within 12 months
- Pregnant or breast-feeding women
- Patients under guardianship
- Polymicrobial bacteremia including S. aureus
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Interventions
Nasal swab to detect nasal carriage of S. aureus
Peripheral venous sampling to collect peripheral blood mononuclear cells.
Antibiotic treatment for bacteremia (+/- 1 month), in all patients with S. aureus
A new nasal swab will be taken using the same technique, to see whether or not the carriage persists
In the event of positive carriage, a new intracellular reservoir test will be performed. A search for relapse (new S. aureus infection) or recurrence (S. aureus bacteremia if the 1st bacteremia was due to another pathogen) will be carried out.
Locations(1)
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NCT06594250