RecruitingNot ApplicableNCT06595719

Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis

Assessing Gut Microbiota, Mucosal Healing Markers, and Metabolites in Mild to Moderate Ulcerative Colitis Treated With Multi-Strain Probiotics


Sponsor

National University of Malaysia

Enrollment

124 participants

Start Date

Feb 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Probiotics are one of the adjunctive treatments that have been extensively explored for Ulcerative colitis (UC) disease management. Probiotics, a group of beneficial bacteria, can bring various health benefits when adequately supplied to the body, especially for gut wellness. In particular, for UC patients, gut dysbiosis is one of the contributing factors in their pathogenesis. Thus, the supplementation of probiotics in combination with standard treatment can potentially help in relieving symptoms as well as promoting mucosal healing for long-term remission.


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding a multi-strain probiotic supplement to standard treatment can improve outcomes for people with mild to moderate ulcerative colitis (UC), an inflammatory bowel disease that causes ongoing inflammation of the large intestine. **You may be eligible if...** - You have been diagnosed with UC confirmed by colonoscopy - Your UC affects at least the lower part of your colon - Your disease is mild to moderate in severity - You have been on medication for at least 4 weeks **You may NOT be eligible if...** - You have Crohn's disease or pouchitis - Your UC is severe - You used antibiotics in the last 2 weeks - Your UC medication dose changed in the last 4 weeks - You used probiotics (prescription or over-the-counter) in the last 2 weeks - You used anti-inflammatory painkillers (NSAIDs) in the past week Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTMulti-Strain Probiotics

Each sachet of the multi-strain probiotics contain 30 billion CFU of 6 strains which includes Lactobacillus acidophilus BCMC®12130, Lactobacillus casei subsp BCMC®12313, Lactobacillus lactis BCMC®12451, Bifidobacterium bifidum BCMC®02290, Bifidobacterium infantis BCMC®02129, Bifidobacterium longum BCMC®02120

DIETARY_SUPPLEMENTPlacebo

Replicate for multi-strain probiotics without any active ingredients


Locations(1)

Hospital Canselor Tuanku Muhriz UKM

Cheras, Kuala Lumpur, Malaysia

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06595719


Related Trials