RecruitingNot ApplicableNCT06597227

Proximal Gastrectomy vs Total Gastrectomy in Locally Advanced Upper Gastric Cancer After Neoadjuvant Therapy

Comparison of Clinical Efficacy of Proximal Gastrectomy vs Total Gastrectomy in Locally Advanced Upper Gastric Cancer After SOX Combined With Anti-PD-1 Neoadjuvant Therapy：a Prospective, Multi-center, Randomised，Controlled Trial

Sponsor

Guihua Wang

Enrollment

404 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Locally Advanced Gastric Cancer

Summary

We plan to evaluate the efficacy and safety of proximal gastric vs. total gastric radical resection after SOX combined with anti-PD-1 neoadjuvant therapy in locally advanced upper gastric cancer

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of stomach cancer surgery — removing only the upper part of the stomach (proximal gastrectomy) versus removing the whole stomach (total gastrectomy) — in patients with upper gastric cancer who first receive chemotherapy to shrink the tumor before surgery. **You may be eligible if...** - You are between 18 and 75 years old - You have confirmed upper stomach (gastric) cancer that is locally advanced - The cancer is considered removable by surgery - You have not yet received any cancer treatment for this diagnosis - You have a good performance status (ECOG 0-1) - Your blood counts and organ function meet study thresholds **You may NOT be eligible if...** - You have already received cancer treatment for this disease - Your cancer has spread to distant organs - You have serious heart, liver, kidney, or other organ problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREProximal radical gastrectomy

Proximal radical gastrectomy : Dissection of lymph nodes No.1,2,3a,4sa,4sb,7,8a, 9, 11p, 11dare recommended. The tumor involved more than 3cm of esophagus and additional dissection No.19, 20, 110. Gastrointestinal reconstruction method: double channel anastomosis is recommended, and other anastomosis methods can be carried out according to the surgeon\'s habit.

PROCEDURETotal radical gastrectomy

total radical gastrectomy : Dissection of lymph nodes No.1-7, 8a, 9, 11p, 11d, 12a are recommended. The tumor involved more than 3cm of esophagus and additional dissection No.19, 20, 110. Gastrointestinal reconstruction method: Roux⁃en⁃Y anastomosis is recommended

Locations(1)

Tongji Hospital, Huazhong University of Science and Technology

Wuhan, Hubei, China

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NCT06597227

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