RecruitingNot ApplicableNCT06598150

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord fMRI in Chronic Hemiparetic Stroke

Sponsor

Northwestern University

Enrollment

32 participants

Start Date

May 20, 2023

Study Type

INTERVENTIONAL

Conditions

Hemiparesis Stroke

Summary

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Eligibility

Min Age: 18 Years

Inclusion Criteria10

Adults aged at least 18y
Able to perform shoulder abduction task (confirmed during screening and initial examination)
Safe to undergo MRI
Able to follow visual instructions using MRI-compatible vision correction goggles
No brainstem or cerebellar lesions
No severe concurrent medical problems
Cognitive/attentional capacity to focus on a task
Able to communicate in English or Spanish
Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).

Exclusion Criteria14

MRI contraindications
Severe claustrophobia
Pregnant women
Prisoners
Vulnerable populations
Diagnosis/history of:
multiple sclerosis
brain tumor
brain radiation
traumatic brain injury
dementia
Parkinson's disease
Concurrent enrollment in an intervention study
Concurrent use of medications known to suppress central nervous system activity

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Interventions

OTHERShoulder Abduction

Individuals will be visually cued to perform short, unilateral, isometric shoulder abduction tasks. A visual display will provide real-time feedback of the shoulder abduction torque, to help the participant target a predetermined torque level.