RecruitingNCT06600568

Novel Therapeutic Approach for Human T-cell Malignancies

Identification of Targetable Vulnerabilities in Redox Homeostasis Pathways as a Novel Therapeutic Approach for Human T-cell Malignancies


Sponsor

Istituto Oncologico Veneto IRCCS

Enrollment

120 participants

Start Date

Jul 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This multicenter translational study, with prospective and retrospective samples, aims to identify new strategies to selectively eliminate neoplastic T cells by modulating intracellular ROS levels. Interactions between drugs capable of activating the apoptotic process (e.g., Venetoclax) and drugs capable of altering ROS homeostasis (e.g., inhibitors of the enzyme glucose-6-phosphate dehydrogenase) will be examined. The most promising compounds will be selected based on results obtained in vitro on cell lines and PDX already available in the laboratory, and then will be assayed ex vivo in cells obtained from patients with resistant/refractory T-cell neoplasms.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new treatment approach for T-cell leukemia and lymphoma — cancers that affect a specific type of immune cell called T-cells. These cancers are rare and can be difficult to treat, so researchers are exploring novel therapies. **You may be eligible if...** - You have been diagnosed with T-cell leukemia or lymphoma (either before or after thymic origin) - You are 18 or older - You are willing to provide written informed consent **You may NOT be eligible if...** - You have a serious medical condition or uncontrolled active infection that would prevent you from receiving standard treatment protocols Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERTranslation analysis

Novel strategies to selectively eliminate neoplastic T cells by modulating intracellular ROS levels.


Locations(2)

Istituto Nazionale Tumori Fondazione G.Pascale

Naples, Italy

Istituto Oncologico Veneto

Padova, Italy

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NCT06600568


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