Modified Platform Trial Evaluating PpLHACM and SOC Versus SOC Alone in the Treatment of Nonhealing DFUs

This study is testing whether a biological membrane graft called PpLHACM, in addition to standard wound care, can help heal stubborn diabetic foot ulcers (open sores on the foot that don't heal) that have not responded to standard treatment alone. **You may be eligible if...** - You are 18 or older - You have type 1 or type 2 diabetes - You have a foot ulcer that is between 0.7 and 5 square centimeters in size - The ulcer has been present between 4 weeks and 12 months despite standard wound care - The ulcer is located below the ankle - The ulcer does not involve exposed bone or tendon - Blood flow to the affected leg is adequate (confirmed by vascular testing) **You may NOT be eligible if...** - The ulcer is infected or has exposed bone/tendon - You have significant circulation problems in the affected leg - You have multiple ulcers very close together (less than 2 cm apart) - You have other conditions that would interfere with wound healing Talk to your doctor to see if this trial is right for you.