To Quantify the Impact of Addition of the GAAD Score to Imaging in Patients with Chronic Liver Disease Eligible for HCC Surveillance.

This study is testing whether adding a blood test called the GAAD score to standard liver imaging can better identify which patients with chronic liver disease (such as cirrhosis or hepatitis) are at high risk for developing liver cancer (hepatocellular carcinoma, or HCC), so it can be caught earlier. **You may be eligible if...** - You have cirrhosis (scarring of the liver) from any cause, OR - You have chronic hepatitis B (without cirrhosis) with a family history of liver cancer or certain elevated risk scores, OR - You have chronic hepatitis C or fatty liver disease (NASH) with advanced liver scarring (F3 fibrosis) **You may NOT be eligible if...** - You have been diagnosed with any cancer other than non-melanoma skin cancer - You have a prior history of liver cancer - You are pregnant or breastfeeding - Your kidney function is significantly reduced (GFR below 45) - You are unable or unwilling to undergo both CT and MRI imaging - Your life expectancy is less than 2 years - You take warfarin or similar blood thinners (vitamin K antagonists) Talk to your doctor to see if this trial is right for you.