Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses
Evaluation of Predisposing Factors for Idiopathic Recurrent Pregnancy Losses: a Study Using a Genomic and Microbiota Approach
Hospital de Clinicas de Porto Alegre
20 participants
Apr 14, 2023
OBSERVATIONAL
Conditions
Summary
Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation. Efforts are being done in the scientific community to solve this cases. In this study, the investigators aim to investigate genetic factors that might predispose to RPL, as well as the influence of the uterine microbiota (microorganisms that normally live in the uterus of women).
Eligibility
Inclusion Criteria2
- RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\'s protocols;
- Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors.
Exclusion Criteria2
- RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses;
- Control group: N/A
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Interventions
An exome will be performed on the participants of RPL group.
A cervical microbiota analysis will be performed in the RPL and control groups.
Locations(1)
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NCT06604338