RecruitingNCT06608160

68Ga-grazytracer PET Assists in Diagnosing Pseudoprogression Following Immunotherapy in Lung Cancer.

68Ga-grazytracer PET/CT Assists in Diagnosing Pseudoprogression Following Immunotherapy in Lung Cancer: a Prospective, Observational Study.


Sponsor

Ruijin Hospital

Enrollment

30 participants

Start Date

Jun 20, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Currently, there are limited methods available in clinical practice to distinguish pseudoprogression after immunotherapy. Most patients rely on follow-up observations to monitor the disease, which does not meet clinical needs. 68Ga-grazytracer is a novel imaging agent targeting granzyme B. By detecting the concentration of granzyme B, it reflects the localization of cytotoxic T cells in the tumor region and their potential ability to kill tumor cells. This study aims to leverage the simplicity, non-invasiveness, visualization, and semi-quantitative advantages of 68Ga-grazytracer PET imaging to evaluate its effectiveness and feasibility in diagnosing pseudoprogression.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a special type of imaging scan called a PET scan using a tracer called 68Ga-grazytracer to help doctors tell the difference between real cancer progression and "pseudoprogression" in lung cancer patients. Pseudoprogression is when tumors temporarily appear larger on scans after immunotherapy — not because the cancer is truly worsening, but because the immune system is attacking it. This distinction is crucial for treatment decisions. **You may be eligible if...** - You have lung cancer confirmed by biopsy - You have been treated with immune checkpoint inhibitor therapy - Your scans show that tumors may have grown or new spots have appeared, and doctors aren't sure if it's true progression or pseudoprogression - You are between 18 and 75 years old - You have a life expectancy of at least 6 months **You may NOT be eligible if...** - You have serious heart, lung, bone marrow, liver, or kidney problems - You have a bowel perforation or complete bowel blockage - You have active blood infections Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

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NCT06608160


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