Autologous Hematopoietic Stem Cell Transplantation Combined With CD19-CART Treatment of Adult High-risk Acute Lymphoblastic Leukemia

This study is testing a combination treatment for adults with high-risk acute B-cell leukemia (a fast-growing blood cancer). The approach combines CAR-T cell therapy — where a patient's own immune cells are engineered to attack cancer — followed by a stem cell transplant using the patient's own stem cells. Researchers want to see if this combination can improve long-term outcomes. **You may be eligible if...** - You are an adult with high-risk acute B-lymphoblastic leukemia - Your cancer went into complete remission after initial chemotherapy - Your CAR-T cells have been successfully manufactured from your own blood - You are healthy enough for a stem cell transplant - Your major organs are functioning well **You may NOT be eligible if...** - You have another active cancer in another organ - You have an uncontrolled serious infection - You test positive for syphilis, HIV/AIDS, hepatitis B, or hepatitis C - You have had allergic reactions to similar medications used in the study Talk to your doctor to see if this trial is right for you.