RecruitingNot ApplicableNCT06608706

The Key to Integrated Trauma Treatment in Psychosis Trial

The Key to Integrated Trauma Treatment in Psychosis (Kit) Trial: A Pragmatic, Multicenter Effectiveness RCT of EMDR for Trauma Symptoms in Schizophrenia Spectrum Disorders


Sponsor

Haukeland University Hospital

Enrollment

187 participants

Start Date

Sep 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Schizophrenia spectrum disorders (SSDs) have a significant trauma etiology: trauma has been reported in 65 - 80% in this patient group and have a negative impact on prognosis. Trauma treatment is currently not offered in SSDs due to a lack of evidence. KIT is a pragmatic trial comparing the effectiveness of added trauma focused therapy, Eye Movement Desensitization and Reprocessing (EMDR) to standard treatment in SSDs. The study will compare EMDR as add on to treatment as usual (TAU) to TAU in patients with schizophrenia spectrum disorders (SSDs). The overall aim is to examine the effectiveness of EMDR on trauma symptoms in SSDs. Participants will receive max. 26 sessions of EMDR, and complete assessments before, during and after the course of therapy, in addition to a period of time (6 months) after therapy to examine long-term effects.


Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This trial, called KITT, is testing whether trauma-focused therapy can safely and effectively help people who have both psychosis (such as schizophrenia) and unresolved trauma. Many people with psychosis have experienced trauma, but they are often excluded from trauma treatment out of caution. This study aims to address that gap. **You may be eligible if...** - You are 16 years or older - You have a diagnosis of a psychotic disorder (such as schizophrenia or related conditions) - You experienced a traumatic event more than 1 month ago and are still distressed by it - You feel motivated to engage in trauma-focused therapy - You are able to understand and give informed consent **You may NOT be eligible if...** - Your primary diagnosis is substance or alcohol dependence - You cannot understand spoken Norwegian - You have organic psychosis or a neurological disorder - You are currently in an acute psychotic episode (hospitalized in an acute ward in the last 6 weeks) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEREye Movement Desensitization and Reprocessing (EMDR) for psychosis

EMDR aims to treat and process trauma by safely retrieving the trauma memories while taxing the working memory. EMDR targets trauma symptoms through memory reprocessing of traumatic memories, and consists of eight flexible phases: history taking/case conceptualization; preparation for memory reprocessing; assessment/identification of a target memory; desensitization/reprocessing; installation of positive cognition; body scan; closure; and re-evaluation. EMDR in the current trial has psychosis-specific adaptations including focus on psychoeducation, preparation for reprocessing and patient safety. Techniques targeting dissociation, psychotic symptoms and psychosis-related challenges are included.


Locations(11)

Haukeland University Hospital

Bergen, Norway

Betanien DPS

Bergen, Norway

Solli DPS

Bergen, Norway

Voss DPS Bjørkeli

Bergen, Norway

Helse Fonna HF

Haugesund, Norway

Diakonhjemmet Hospital

Oslo, Norway

Oslo University Hospital

Oslo, Norway

Helgeland Hospital HF

Sandnessjøen, Norway

Stavanger University Hospital

Stavanger, Norway

UNN

Tromsø, Norway

St. Olav Hospital

Trondheim, Norway

View Full Details on ClinicalTrials.gov

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NCT06608706


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