Caffeine, CYPA12 and Resistance Exercise

This study investigates how a common genetic variation in the CYP1A2 enzyme — which affects how fast the body metabolizes caffeine — influences the performance-enhancing effects of caffeine on muscular strength, power, and endurance during resistance exercise. People with different versions of this gene process caffeine at different speeds, which may explain why caffeine's ergogenic benefits vary so much from person to person. Healthy, physically active adults aged 18–35 with a BMI under 25, without cardiovascular or neuromuscular conditions, are eligible. Participation involves two experimental exercise sessions where participants consume either caffeine or a placebo, perform strength and endurance tests, and provide a genetic sample to identify their CYP1A2 genotype. This summary was prepared to help patients understand the study in plain language.