RecruitingPhase 1NCT06612840

A Study of GNC-077 in Patients With Locally Advanced or Metastatic Non-small-cell Lung Cancer and Other Solid Tumors

An Open-label, Multicenter, Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics Characteristics or Preliminary Efficacy and Antitumor Activity of GNC-077 Multi-specific Antibody Injection in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Other Solid Tumors


Sponsor

Sichuan Baili Pharmaceutical Co., Ltd.

Enrollment

20 participants

Start Date

Oct 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is an open-label, multicenter, dose-escalation and cohort expansion phase I clinical study to evaluate the safety, tolerability, pharmacokinetics characteristics or preliminary efficacy and antitumor activity in patients with Locally advanced or metastatic non-small cell lung cancer and other solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new drug called GNC-077 in people with advanced non-small cell lung cancer (NSCLC) or other solid tumors. It is an early-phase trial that first checks how safe the drug is and then looks at whether it helps shrink tumors. **You may be eligible if...** - You are between 18 and 75 years old (or 18 and older in Stage Ib) - You have locally advanced or metastatic non-small cell lung cancer, or another solid tumor - Your cancer has progressed after standard treatments - You are in good physical health (ECOG 0–1) **You may NOT be eligible if...** - You have active brain metastases that are untreated or unstable - You have an active autoimmune disease or are on immune-suppressing medications - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGNC-077

Administration by intravenous infusion for a cycle of 3 weeks.


Locations(1)

Shanghai East Hospital

Shanghai, Shanghai Municipality, China

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NCT06612840


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