Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

This study uses multiple advanced brain imaging scans — including two types of PET tracers and specialized MRI — to build a detailed picture of how glioblastoma (an aggressive brain tumor) uses energy and nutrients. Better metabolic profiling could help doctors understand tumor behavior and plan more targeted treatments. **You may be eligible if...** - You are 18 years old or older - You have a new brain mass suspected or confirmed to be glioblastoma - Or you have a previously treated glioblastoma showing signs of possible recurrence on imaging **You may NOT be eligible if...** - You are unable to have MRI or PET scans (e.g., metal implants, claustrophobia) - You are pregnant or breastfeeding - You have a serious medical condition that makes the imaging procedures unsafe Talk to your doctor to see if this trial is right for you.