RecruitingNCT06614998

Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis a Multi-center, Prospective Study

Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis: a Multi-center, Prospective Study


Sponsor

The Affiliated Hospital of Xuzhou Medical University

Enrollment

80 participants

Start Date

May 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Our three-step screening system uses commonly used clinical and laboratory parameters to effectively identify patients who may be at high risk of HLH, conduct etiology screening early for patients who meet the diagnostic criteria for HLH, and guide standardized treatment. Therefore, this study proposes to establish a highly accurate and convenient hemophagocytic early warning system to improve the early diagnosis of patients with hemophagocytic syndrome and identify suspected HLH patients early. Etiology screening is performed on patients who meet the diagnostic criteria for HLH, high-risk predisposing factors are identified, and precise treatment is guided, thereby improving the success rate of patient treatment and improving the quality of life.


Eligibility

Inclusion Criteria3

  • Subjects must meet all of the following criteria:
  • Patients who meet the first step screening + have ≥ 3 abnormal screening indicators in the second step
  • Patients who meet the first step screening + have 2 abnormal screening indicators in the second step + patients with high-risk factors for HLH, such as history of lymphoma, EBV infection, autoimmune diseases, etc

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGPatients diagnosed with HLH-94 should be treated as soon as possible

For some highly suspicious patients, after diagnosis, according to the patient's etiology, the treatment plan should be determined as soon as possible, such as lymphoma-related patients treated with hormones combined with etoposide, which can greatly improve the prognosis of patients


Locations(1)

Affilitated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06614998


Related Trials