RecruitingNot ApplicableNCT06618313

One Trial to Evaluate the Safety, Tolerability and Efficacy of JCXH-213 in Patients With r/r B-NHL

Open-label, Single-arm,Exploratory Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of JCXH-213 in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma


Sponsor

Beijing GoBroad Hospital

Enrollment

8 participants

Start Date

Mar 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Evaluate the Safety and Efficacy of JCXH-213 in Patients with Relapsed/Refractory B-cell non-Hodgkin Lymphoma


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing JCXH-213 — a new CAR-T cell therapy that targets the CD19 protein on cancer cells — in people with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). This includes several types of B-cell lymphoma that have come back or stopped responding after prior treatments. **You may be eligible if...** - You have been confirmed to have CD19-positive B-cell non-Hodgkin lymphoma (including DLBCL, follicular lymphoma, PMBCL, HGBCL, or transformed B-cell lymphoma) - Your cancer has relapsed or did not respond to prior treatment - You are in reasonably good health (ECOG score 0–1) - You have measurable lymphoma on scans - Your organ function meets the required levels **You may NOT be eligible if...** - You have active brain involvement from the lymphoma - You have had certain prior CAR-T or gene therapies - You have serious infections, autoimmune conditions, or organ failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGJCXH-213,an mRNA-LNP based in vivo CAR therapy

JCXH-213 infusion


Locations(1)

Department of Lymphoma and Myeloma, Yuhengnan Road, Changping District, Beijing

Beijing, China

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NCT06618313


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