A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers

This trial is testing a special wound dressing called PCMP — which contains a collagen matrix infused with an antimicrobial agent — compared to standard wound care alone, for people with diabetic foot ulcers that have not healed despite prior treatment. Diabetic foot ulcers are a serious complication of diabetes and are a leading cause of amputation. **You may be eligible if...** - You are 18 or older with Type 1 or Type 2 diabetes - Your target wound is at least 1 cm² in area and has been present for at least 4 weeks without healing - The ulcer is on your foot (at least half of it below the ankle bone) - The wound is classified as Wagner Grade 1 or 2 (not deeply infected or gangrenous) - Blood flow to your leg is adequate - If the wound is on the sole of your foot, it has been properly offloaded (pressure relieved) for at least 14 days **You may NOT be eligible if...** - Your wound has a bone or deep tissue infection - Your blood flow to the leg is severely compromised - Your blood sugar is very poorly controlled - You have an active systemic infection Talk to your doctor to see if this trial is right for you.