RecruitingNCT06622798

Exploratory Study on the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients

A Retrospective Study Exploring the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients


Sponsor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Enrollment

470 participants

Start Date

Aug 20, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This study plans to retrospectively include 470 initial surgical specimens from 470 patients with epithelial ovarian, fallopian tube or primary peritoneal cancers who were treated with PARPi maintenance therapy in the hospital from 2018.01 to 2024.01. All patients included would be scored by the proprietary HRD ADx-GSS® algorithm with the detecting results of the three genomic statuses including heterozygous omission (LOH), telomere allelic imbalance (TAI), and large-segment translocation (LST). Finally, the correlation between the HRD scores and the prognosis of Chinese ovarian cancer patients and the efficacy of using PARPi as maintenance treatment would be explored.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines the relationship between a test called HRD (homologous recombination deficiency) score and how well PARP inhibitors — a type of targeted therapy — work in women with advanced ovarian, fallopian tube, or peritoneal cancer. Researchers want to understand which patients benefit most from this treatment. **You may be eligible if...** - You are a woman aged 18 or older - You have advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer diagnosed after January 2015 - You are receiving or have received PARP inhibitor maintenance therapy after chemotherapy - You are in good health with stable CA125 levels (ECOG 0–2) - You have adequate heart, liver, and kidney function **You may NOT be eligible if...** - You have had another cancer within the last 5 years - You are unable to understand or cooperate with study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNon-interventional

Non-interventional


Locations(1)

Sun Yat-sen memorial hospital

Guangzhou, Guangdong, China

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NCT06622798