Blue-Light Photodynamic Therapy and Sonidegib for Multiple Basal Cell Carcinomas

This study tests a combination of blue-light photodynamic therapy (a light-activated treatment) and sonidegib (a targeted oral drug) for people with multiple basal cell carcinoma (BCC) skin lesions. BCC is a common type of skin cancer, and this study is designed for patients who have multiple lesions and are not good candidates for surgery. **You may be eligible if...** - You are 18 or older - You have at least 3 nodular BCC lesions (each between 0.5 and 5 cm) on the head, neck, trunk, or limbs - Your diagnosis has been confirmed clinically, with 1–3 lesions biopsied - You are not a surgical candidate, or surgery would be risky, impractical, or disfiguring - You have not had prior treatment for these lesions **You may NOT be eligible if...** - You have only a single BCC lesion that can be easily removed - You have been previously treated with a hedgehog pathway inhibitor - You have serious health conditions that make you ineligible for either treatment Talk to your doctor to see if this trial is right for you.