Hilotherapy for Prevention of Chemotherapy-induced Peripheral Polyneuropathy
Hilotherapy for Prevention of Chemotherapy-induced Peripheral Polyneuropathy - a Unicentric, Prospective-controlled, Randomized Clinical Trial for Comparison of Local Hilotherapy Vs. No Therapy to Prevent Peripheral Polyneuropathy During Taxan-based Chemotherapy Regimen
University of Ulm
150 participants
Apr 17, 2024
INTERVENTIONAL
Conditions
Summary
Prospective study of hilotherapy of hands and feet as prevention of chemotherapy-induced peripheral polyneuropathy induced by Taxan-based chemotherapy regimen that are used in the therapy of breast cancer and genital malignoma of the women.
Eligibility
Inclusion Criteria7
- Written consent for participation in this trail
- Age ≥18 years
- Female
- Breast or genital cancer of the woman
- Planned application of a Taxan-based chemotherapy regimen (Paclitaxel, Nab-Paclitaxel, Docetaxel) independent of the therapy line
- Taxan- and Platin-naivity
- Sufficient knowledge of the German language to assure an adequat survey of patient's history
Exclusion Criteria5
- pre-existing peripheral polyneuropathy
- chemotherapy with taxan- and/or carboplatin-based regimens in a preceding therapy
- Existence of one of the following diseases: Diabetes mellitus (of any type), neurological diseases that are involving peripheral nerve damage (e.g. Multiple Sclerosis, Amytrophic lateral sclerosis, Parkinson's disease), chronic pain syndrome, Cryoglobulinemia, cold hemagglutination, cold hives / cold contact hives, Raynaud's disease, significant peripheral artery disease,
- Lack of knowledge of German
- Males
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Interventions
Hilotherapy
Locations(1)
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NCT06627348