RecruitingNot ApplicableNCT06627634

Radical Surgery for Advanced Gastric- or GEJ-cancer With Oligometastatic Dissmination to the Liver

Gastric Cancer and Oligometastatic Liverinvolvement. Metastatectomy and Impact on Survival


Sponsor

Aarhus University Hospital

Enrollment

20 participants

Start Date

Dec 1, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

Offering treatment with potential to cure for participants with no such offer in today's standard treatment options, by offering metastatectomia and standard treatment with intention to cure i.e., neoadjuvant chemotherapy and gastrectomy for participants with gastric- og gastroeusofageal junction cancer. Including 20 participants from all 4 centres in Denmark able to perform the surgical procedures in question. Endpoints: 2-year overall survival.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether surgery to remove both the primary stomach or gastroesophageal junction (GEJ) cancer and a limited number of liver metastases — combined with chemotherapy — can improve survival in patients with a small amount of spread ("oligometastatic" disease). **You may be eligible if...** - You are over 18 years old - You have stomach or GEJ adenocarcinoma with up to 30% liver involvement - Both the primary tumor and liver deposits appear removable on imaging - You are in good surgical health (ASA score ≤ III, WHO performance status 0–1) - You are able to receive FLOT chemotherapy **You may NOT be eligible if...** - Your cancer is not surgically removable - Your cancer is growing directly into major nearby organs (pancreas, major blood vessels, bones) - You have had another cancer diagnosis in the past 2 years (minor exceptions apply) - You have had prior surgery on your esophagus, stomach, or upper gut Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREMetastatectomia and standard treatment for resectable disease.

Rather than palliative chemotherapy, the intervention offered to participants is preoperative chemotherapy, resection of primary tumour and metastatectomia of oligometastatic spread to the liver. If fit for post-operative chemotherapy, this is offered as well.


Locations(1)

Aarhus Univercity hospital

Aarhus, Jylland, Denmark

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NCT06627634


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