RecruitingPhase 2NCT06627738

Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost

Sponsor

Centre Antoine Lacassagne

Enrollment

42 participants

Start Date

Jun 10, 2025

Study Type

INTERVENTIONAL

Conditions

Carcinoma, Non-Small Cell Lung

Summary

This is a monocentric, non-randomized, open-label, superiority phase II clinical investigation evaluating the efficacy of additional Cyberknife irradiation after a doublet of Platinum Salts-based chemotherapy and concomitant radiotherapy in patients with locally advanced non-small cell lung carcinoma (NSCLC), with an interim analysis.

Eligibility

Min Age: 18 Years

Inclusion Criteria13

Patients aged 18 years old or more
ECOG 0 to 2
Histologically proven non-small cell lung cancer
Stage III non-metastatic tumor, not allowing for immediate surgery
Volume(s) on the evaluation chest CT scan done at the end of conventional radiotherapy (between 34 \& 46 Gy) meeting the following criteria:
to 3 target volumes of less than 5 cm in greatest diameter
And allowing for the delivery of a CyberKnife boost to be carried out in compliance with the manufacturer requirements and with the doses delivered to the organs at risk (OAR/fractions) defined in appendix 2
Patients who have received a " Taxcis " treatment consisting in 2 cycles of induction chemotherapy (platinium-based doublet) and then at least 40 Gy of irradiation in combination with at least 2 cycles of concomitant chemotherapy (platinium-based doublet)
No contraindication to implantable venous devices (IVDs)
Patient who has read the patient information note and signed the consent form
If applicable, negative pregnancy test\*
Eligible for National Health Insurance in France
Chest CT scan performed prior to Taxcis

Exclusion Criteria9

Positive EGFR mutation
Exercise-induced dyspnea associated with heart failure equal to or greater than stage III of the New York Heart Association (NYHA) classification, (appendix 3)
Coronary syndrome or heart failure in the last three months
Pulmonary function test contraindicating radiotherapy: PFT-FEV1 inferior to 1 L.
After radio-chemotherapy, presence of any toxicity contraindicating Cyberknife irradiation
Vulnerable populations and participants as defined in Articles 64 to 68 of Regulation (EU) 2017/745 of the European Parliament and of the Council of 5 April 2017:
Incapacitated participants who have not given or refused informed consent prior to the onset of their incapacity, who are not under the provisions of article 64 ;
Pregnant or breast-feeding women who are not covered by the provisions of article 66 ;
Adults under legal protection or unable to express their consent.

Interventions

RADIATIONCyberknife irradiation

Additional Cyberknife irradiation after a doublet of Platinum Salts-based chemotherapy and concomitant radiotherapy in inoperable patients with locally advanced non-small cell lung carcinoma