Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP
Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP on Elderly Living On Community in Bandung
Universitas Padjadjaran
17 participants
Sep 15, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\[s\] it aims to answer are: 1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise? 2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise? 3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise? 4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise? Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks
Eligibility
Inclusion Criteria4
- Frailty level is in pre-frailty
- MoCA INA score above 18
- Domicile in Bandung City
- Willing to participate in the study after informed consent
Exclusion Criteria9
- There is a hearing impairment that may prevent the subject from receiving verbal instructions
- There is uncorrected visual impairment
- There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables
- Subjects received other rehabilitation programs
- Post-stroke with average limb muscle strength below three
- There are diseases that cause impaired cognition such as Alzheimer\'s disease, traumatic head injury, Parkinson\'s disease.
- There are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program.
- Severe cardiovascular disease as assessed by a heart and vascular specialist
- Unable to attend Exercises regularly
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Interventions
Exercise training that consists of flexibility, aerobic, balance and strengthening regime. The exercise given three times a week, for 12 weeks.
Locations(1)
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NCT06628895