A Phase III Study of YL201 in Recurrent or Metastatic Nasopharyngeal Carcinoma
A Randomized, Controlled, Multicenter Phase III Clinical Study of YL201 Versus Investigator's Choice of Chemotherapy in Subjects with Recurrent or Metastatic Nasopharyngeal Carcinoma Who Have Failed Prior PD-(L)1 Inhibitor and At Least Two Lines of Chemotherapy
MediLink Therapeutics (Suzhou) Co., Ltd.
400 participants
Dec 31, 2024
INTERVENTIONAL
Conditions
Summary
This study was designed to compare the efficacy and safety of YL201 with Investigator's choice of chemotherapy in subjects with recurrent or metastatic nasopharyngeal carcinoma who have failed prior PD-(L)1 inhibitor and at least two lines of chemotherapy.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
YL201 will be administered intravenously on Day 1 of each 3-week cycle at RP3D dose level.
Docetaxel will be administered intravenously at 75 mg/m2 on Day 1 of each 3-week cycle.
Capecitabine will be administered orally at 1000 mg/m2 twice a day (BID) on Days 1 to 14 of each 3-week cycle
Gemcitabine will be administered intravenously at 1000 mg/m2 on Day 1 and 8 of each 3-week cycle
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06629597