Naltrexone for Overdose Prevention

This study is testing whether naltrexone, a medication used to reduce cravings, can help prevent drug overdoses in people who use stimulants (such as cocaine, meth, or amphetamines) and are at risk for or living with HIV. Stimulant use can impair judgment and increase risky behavior, and this trial explores whether naltrexone can reduce that harm. **You may be eligible if...** - You are 18 or older - You are at risk for HIV or are living with HIV - You have a stimulant use disorder, or have used cocaine, amphetamine, or methamphetamine at least 10 days per month in the past 6 months - You speak English and can provide informed consent **You may NOT be eligible if...** - You currently use opioids (including being prescribed them) or have a new opioid use disorder - You received a long-acting naltrexone injection in the past 30 days - You have planned surgery in the next 6 months - You have moderate to severe liver disease - You are pregnant or breastfeeding - You have a serious bleeding disorder or take blood thinners - You have a known allergy to naltrexone Talk to your doctor to see if this trial is right for you.