RecruitingNCT06635525

Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Enrollment

146 participants

Start Date

Oct 16, 2024

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Disease Requiring Chronic Dialysis Vaccine Response

Summary

The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis. Researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease. Participants will: * Be enrolled at the time of influenza vaccination * Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination * Be asked to provide relevant clinical information and a blood sample at each visit

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria4

Age between 18 and 70 years
Patients undergoing thrice-weekly hemodialysis / peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency
Subjects eligible to receive a seasonal influenza vaccine
Signed informed consent for participation in the study

Exclusion Criteria4

Recent influenza infection (clinically resolved less than 3 months ago).
Administration of immunosuppressive drugs in the two weeks prior to vaccination.
Administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation).
Systemic infection clinically resolved less than two weeks before enrollment.

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