The Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Subjective Tinnitus
Eye & ENT Hospital of Fudan University
120 participants
May 21, 2024
INTERVENTIONAL
Conditions
Summary
The aim of this study is to compare the efficacy of frequency-specific patterned repetitive transcranial magnetic stimulation (rTMS) and 1Hz rTMS for the treatment of chronic subjective tinnitus. In this single-blind randomized controlled study, patients will be randomly assigned 1:1 to receive two different types of rTMS stimulation.
Eligibility
Inclusion Criteria6
- Adults aged between 18 and 80 years old.
- Experiencing persistant subjective tinnitus for at least 3 months.
- A score of 38 or more on THI.
- 50 dB HL or less on the average pure tone threshold (0.5, 1, 2kHz) of the worse ear.
- Voluntarily participate in the study and sign the informed consent form.
- Have normal mental status and cognitive function, and be able to cooperate with the research process.
Exclusion Criteria14
- Diagnosis of Meniere's disease, conductive hearing loss or objective tinnitus.
- History of epilepsy or stroke.
- Diagnosis of acoustic neuroma.
- Severe sensorineural hearing loss.
- Surgically or traumatically implanted ferromagnetic foreign bodies, including but not limited to pacemakers, neurostimulators, prosthetic metal heart valves, aneurysm clips (non-titanium alloy), intraocular metal foreign bodies, cochlear implants, metal prostheses, metal joints, fixed steel plates or steel pins.
- Patients with active metal foreign bodies (metal implants, dentures, contraceptive rings), insulin pumps, etc., who have been evaluated in detail and are at risk for rTMS treatment.
- Patients taking vestibular sedatives, antipsychotics, anxiolytics, antiepileptics, and ototoxic drugs.
- Patients with a recent history of alcohol or drug abuse
- Bell's palsy
- Acute ear infection within the last 1 month
- Inability to cooperate or complete the study process
- Participation in another clinical trial within the last month.
- Have any condition that may affect compliance or safety
- Any other condition that, in the opinion of the investigator, makes enrollment in the study inappropriate.
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Interventions
Patterned repetitive transcranial magnetic stimulation will be performed at specific frequencies and inter-train intervals
Low-frequency rTMS will be performed at a frequency of 1Hz
Locations(1)
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NCT06635967