RecruitingNot ApplicableNCT06639932

We-INtervention Among Chinese HIV-serodiscordant Male Couples

Evaluating the Effects of the We-INtervention Among Chinese HIV-serodiscordant Male Couples in a Randomized Controlled Trial


Sponsor

City University of Hong Kong

Enrollment

320 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

HIV-serodiscordant male couples, in which one male partner is HIV-seropositive and the other is HIV-seronegative, experience multiple risks in HIV care and prevention. As stigma often hinders such couples' access to support and services, leveraging their relational resources is crucial for optimizing their outcomes. The proposed study will assess the efficacy of the three-session We-INtervention focusing on their relationship dynamics to enhance Chinese HIV-serodiscordant male couples' health and well-being. A total of 160 Chinese HIV-serodiscordant male couples (320 individuals: 160 HIV-seropositive and 160 HIV-seronegative) will be randomized at a 1:1 ratio to either the intervention or control arm. In the intervention arm, the We-INtervention will be delivered to both partners of each couple separately. In the control arm, each couple will receive health information pamphlets.


Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study (We-IN) tests a couples-based intervention designed to help HIV-negative partners in male same-sex couples where one partner is HIV-positive (serodiscordant couples) in China. The program aims to support the HIV-negative partner in starting or staying on PrEP (a medication that prevents HIV transmission) by involving both partners together. **You may be eligible if...** - Both of you are male and 18 or older - You have been in a committed relationship together for at least 3 months - One partner is HIV-positive and the other is HIV-negative - Both partners have told each other their HIV status - Both partners are willing to participate **You may NOT be eligible if...** - Either partner has a chronic illness such as cancer or coronary heart disease - Either partner is unable to complete the study assessments due to low literacy or serious physical or mental health limitations Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALWe-INtervention

The We-INtervention focuses on the relationship dynamics of HIV-serodiscordant male couples. In developing the intervention, we reviewed relevant theories and frameworks, such as the cognitive transactional model, the systemic transactional model, the dyadic illness management model, and the intersectional framework of stigma. The three weekly 60-minute sessions are Session 1: We-disease appraisal. Despite stigma related to their dual minority identities, couples develop a perception of HIV as a shared disease, enhancing illness control. Session 2: Couple communication. Couples undertake skill-building exercises on effective communication techniques to strengthen their relationship. Session 3: Dyadic coping. Couples learn to optimize preference and value assessments in HIV management. A few skill-building exercises help them mobilize and maintain mutual support and develop joint problem-solving skills.

BEHAVIORALUsual Care Group

The participants in the control condition will receive health information pamphlets. The HIV-seropositive partners will receive information on HIV-related knowledge (e.g., symptoms, comorbidity, stages, and opportunistic infection), treatment (e.g., ART and side effects), and management (e.g., nutrition and mental health). The HIV-seronegative partner will receive information on HIV transmission (e.g., risk factors), prevention (e.g., safe sex and PrEP), and testing.


Locations(4)

Fangzhouai Garden

Xiamen, Fujian, China

Guangzhou Yuele Healthcare Service Center

Guangzhou, Guangdong, China

Community Always There

Shenzhen, Guangdong, China

Jin Tang Six-Color Rainbow Healthcare Center

Chengdu, Sichuan, China

View Full Details on ClinicalTrials.gov

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NCT06639932


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