Preliminary Characterization of Commercial Kratom Extract Products

Exclusion Criteria11

• \) Reports any acute adverse or unexpected or otherwise sudden health event related to their typical kratom product dose that occurred within 30 days of screening;
• \) Having ever sought medical attention for an acute adverse health event as a result of taking any kratom product;
• \) Cannot or will not provide their kratom extract product samples in the form of an unopened package that is clearly labeled with at least the product and vendor name;
• )The kratom extract product used by the participant has any semi-synthetic or fully synthetic ingredient listed or is known by the study team to have such an ingredient;
• \) Currently breastfeeding or pregnant;
• \) history or current diagnosis of psychotic disorder;
• \) current untreated bipolar disorder; 8) current untreated major depressive disorder;
• \) Current physical dependence on alcohol, benzodiazepines, or opioids (self-reported or otherwise evidenced) requiring medical intervention;
• \) Reports use of fentanyl within the past month and/or has a fentanyl positive drug screen;
• \) Discordance between self-reported substance use and drug screen results obtained during screening;
• )Any physical, psychiatric, environmental, situational, or kratom product-related condition considered by the study team to increase risk or undue burden.