RecruitingNCT06642324

Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas

Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh

Sponsor

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Enrollment

550 participants

Start Date

Apr 30, 2024

Study Type

OBSERVATIONAL

Conditions

Head & Neck Cancer Oropharyngeal Neoplasms

Summary

Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring the connection between HPV (human papillomavirus) infection and genetic changes in head and neck squamous cell cancers, to better understand how HPV may drive cancer development in these tumors. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with squamous cell carcinoma of the head and neck (oral cavity, oropharynx, throat, larynx, or tongue), confirmed by biopsy - You have provided your consent to participate **You may NOT be eligible if...** - You are under 18 years old - You have a cancer in a part of the body other than the head and neck - You do not have head and neck squamous cell carcinoma - You have chronic diseases, genetic diseases, or active infections Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTHistopathology, Immunohistochemistry, Real-Time PCR, Sequencing

Histopathology for carcinoma detection, Immunohistochemistry for carcinoma-related protein expression, Real-Time PCR for HPV association and HPV typing, Sequencing for genetic study or mutation analysis.