Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas
Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
550 participants
Apr 30, 2024
OBSERVATIONAL
Conditions
Summary
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.
Eligibility
Inclusion Criteria4
- Patient Age: adult (\> 18 years)
- Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC).
- Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue)
- Patient's Consent
Exclusion Criteria4
- Patient Age: children (\< 18 years)
- Cancers of any part of the body other than the head-neck region.
- People without HNSCC
- Any chronic diseases, genetic diseases, acute/chronic infectious diseases, etc. -
Interventions
Histopathology for carcinoma detection, Immunohistochemistry for carcinoma-related protein expression, Real-Time PCR for HPV association and HPV typing, Sequencing for genetic study or mutation analysis.
Locations(1)
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NCT06642324