RecruitingNot ApplicableNCT06642675

nTMS for Negative Symptom in Schizophrenia

Effectiveness of Navigated Transcranial Magnetic Stimulation (nTMS) of Left Supramarginal Gyrus for Negative Symptoms : A Double-blind, Randomized Controlled Trial


Sponsor

Central South University

Enrollment

40 participants

Start Date

Nov 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This research aims to test the effectiveness of Navigated transcranial magnetic stimulation (nTMS) of left Supramarginal Gyrus for negative symptoms. In this double-blind, randomized controlled trial, patients will be assigned to active iTBS experimental group or sham iTBS group. Treatment will last for 10 days, and data will be collected at baseline, 1 day and 1 month after treatment.


Eligibility

Max Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether navigated transcranial magnetic stimulation (nTMS) — a non-invasive brain stimulation technique — can help reduce the "negative symptoms" of schizophrenia, such as emotional flatness, lack of motivation, and social withdrawal. **You may be eligible if...** - You have a confirmed clinical diagnosis of schizophrenia - You score above a certain level on standard assessments of negative symptoms - You are under 60 years old **You may NOT be eligible if...** - You have bipolar disorder, neurodevelopmental disorders, or substance use disorder (other than alcohol or tobacco) - You have a severe physical illness (including brain injury, serious heart or lung conditions) - You have a known genetic syndrome - You have metal implants, epilepsy, or cochlear implants that would prevent TMS or MRI - You are at high risk of self-harm or suicide Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEIntermittent theta burst stimulation(iTBS)

By using the TMS Navigation System, the iTBS will be targeted at the left Supramarginal Gyrus.iTBS will be performed using Magstim Rapid² stimulator, parameters are set to triplet 50Hz bursts, repeat at 5Hz, 2s seconds on and 8 seconds off, 1800 pulses per session, intensity of 90% resting motor threshold(RMT), total duration of 10 minutes.

DEVICESham stimulation

Patients in sham group would receive the same intervention procedure as the active ITBS group, but the coil will be replaced with sham coil, which provides the sensation of TBS without enough magnetic energy to reach the cortex.


Locations(1)

Mental Health Institute of Second Xiangya Hospital,CSU

Changsha, Hunan, China

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NCT06642675


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