Acetazolamide for Treatment Resistant Schizophrenia

This trial is testing whether a medication called acetazolamide (commonly used for altitude sickness and glaucoma) can help people with schizophrenia whose symptoms have not improved despite trying multiple antipsychotic drugs. Researchers want to know if it can be a useful add-on treatment. **You may be eligible if...** - You are between 18 and 55 years old - You have schizophrenia with significant ongoing symptoms (positive symptoms like hallucinations or delusions) despite trying at least two different antipsychotic medications - You have been on a stable dose of your current antipsychotic for more than 1 month - You are not currently enrolled in another clinical trial **You may NOT be eligible if...** - You have used substances or have a substance dependence recently (past month or 6 months) - You have epilepsy or other unstable neurological conditions - You are pregnant - You have kidney problems, Addison's disease, or certain types of glaucoma - You have ever taken acetazolamide or are allergic to it - You have an intellectual disability Talk to your doctor to see if this trial is right for you.